Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 ;
Alternative:
Phospholipase C-zeta-1 (PLC-zeta-1) ;Phosphoinositide phospholipase C-zeta-1 ;
Organism:
Chicken (Gallus gallus).
General Annotation
Sub Unit:
Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Subcellular Location:
Nucleus
Cytoplasm
perinuclear region
Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
Protein Attributes:
50:
MEENRWFLNI | IQDGFMNGKI | DFDSTVKLLE | KLHMPFNLAH | VKHVFKKTVD |
100:
KRKIHTINIE | DFRAIYRAIV | HRNEFHEIFC | AYSENRKNLA | DTELTAFLKK |
150:
EQFKTEGAET | TALEVILKYE | PIDEVRKRRQ | LSFEGFIRYM | SSEDCTIFKK |
200:
EHRTVYQDMN | HPLCDYFISS | SHNTYLVSDQ | LIGPSDLNGY | ISALLKGCRC |
250:
LEIDCWDGSN | NDPVVYHGHT | LTSKITFCSV | IHVVDKYAFA | ASDYPVVLSL |
300:
ENHCSTKQQE | RIAQYLLNIL | GDKLLTSPIG | DIEVTQLPSP | EALKFKILVK |
350:
NKKCGTIEET | MLRKGRDSHG | ETGEVSEEEI | TSSDEETDEK | TPLYPKSGSS |
400:
KRKSEGRSSP | PPRKKAKVKK | MKIAMGLSDL | VIYTKSEKFV | SFEHSLAHQK |
450:
CYENNSIGEL | KAQKFVKHAA | NQFVSHTSRF | ITRIYPKGTR | AGSSNYNPQE |
500:
FWNVGCQMVA | LNFQTSGTPM | ELQNGKFLDN | GGCGYILKPE | FLRNRNSTFN |
550:
PHNVGRYSNP | LSLSIRLISG | HQLPPSNLSK | SNKADPLVQL | EIYGVPEDQA |
600:
KRKSSVIKSN | ALSPRWDETF | SFTVQVPELA | LIRFCVQDEI | SLVANDFLGQ |
637:
YTLPLLSLSK | GYCTVPLFSK | SGGKLEPASL | FVYVWYY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Bovine
ELISA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Chicken 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
tissue :
Testis .